| Achievement/Trophy | Description |
| First Step into Darkness | Complete the game on Casual difficulty. |
| Another Day on the Job | Complete the game on Survival difficulty. |
| Master of Horror | Complete the game on Nightmare difficulty. |
| Every Nook and Cranny | Collect every collectable in the game. |
| Master of Unlocking | Open up all the lockers in the save room. |
| Hardbody | Fully upgrade all of Sebastian's attributes. |
| My Best Friend | Completely upgrade one weapon. |
| The Power of Three | Completely upgrade three weapons. |
| Unstoppable Arsenal | Completely upgrade all weapons. |
| Why Can't I Hold All This Ammo? | Upgrade all options in the Stock menu. |
| Blow Up the Playing Field | Use a secret explosive weapon to kill 10 enemies. (Agony Bolt effects negate results) |
| Full House | Kill 5 enemies with each type of Agony Bolt. |
| Silent Kill | Kill 5 enemies in a row with a sneak kill without being discovered. |
| Burn, Baby, Burn! | Kill 5 enemies with a torch. |
| ...And the Corpses Mount | Kill 30 enemies. |
| Krimson PD Fury | Kill 200 enemies. |
| One Man Army | Kill 400 enemies. |
| Ammo Conservationist | Kill 25 enemies with melee attacks. |
| Bloody Bar Brawl | Sneak Kill an enemy after hitting them with a bottle. |
| Drop It Like It's Hot | Kill 3 living enemies with one drop of a match. |
| The Quick and the Dead | Finish the game with a clear time of under 5:00:00. |
| It Is What It Is | Finish the game without upgrading any skills with green gel. |
| You Asked for It | Finish the game on 悪夢(AKUMU) mode. |
| A la Corvo | Have they lost their minds? Better get past them without a fight. (Ch.2) |
| Knife Beats Chainsaw | His engine roars, but my knife is strong enough to take him out. (Ch.3) |
| Home Is Where the Hospice Is | That vision in the hospice... why here? Why now? (Ch. 4) |
| Not Part of the Job Description | The water's rising, but we'll get out of this without a scratch. (Ch. 5) |
| Everybody Gets One | Who wouldn't reach out for a man clinging for his life? (Ch. 6) |
| I Don't Have Time for This! | It won't stay dead! Better only fight when I have to. (Ch. 7) |
| Item Management | This cave echoes like crazy. Better put the gun away and keep quiet. (Ch. 8) |
| Bathed in Flames | Enough running! I'll burn her to the ground right here! (Ch. 10) |
| Not a Scratch on Her! | I'm not taking any chances, this bus can't take much more damage. (Ch. 12) |
| Entry Level Electrician | I should get this whole generator panel running just in case. (Ch. 14) |
| Weapon of Choice | Defeat the Sadist within the village. |
| Old Flame | Finish off a shrieking beast. |
| Two on Two | Take out both guardians before the church. |
| What's in the Box?! | Escape the Keeper beneath the catacombs. |
| The First, Not the Last | End a monstrosity in the underground garage. |
| Arachnophobia | Outrun a gigantic threat in the city. |
| Slither Into Oblivion | Remove an invisible enemy from the equation. |
| One of the Many | Defeat the ultimate evil within. |
